Inappropriate secretion of antidiuretic hormone deficiency causes

(syndromeofinappropriatesecretionofantidiuretiehormone, SLADH) means the body antidiuretic hormone (ADH) secretion of abnormal increase in activity or its role in extraordinary , Leading to water retention, and increased urinary sodium row of dilution, and other Hyponatremia syndrome. Inappropriate secretion of antidiuretic hormone deficiency (syndromeofinappropriatesecretionofantidiuretiehormone, SLADH) means the body antidiuretic hormone (ADH) secretion, or abnormal increase in the role of extraordinary activity, leading to water retention, and increased urinary sodium row of dilution, and other Hyponatremia syndrome. Inappropriate secretion of antidiuretic hormone cause of disease pathology Inappropriate secretion of antidiuretic hormone deficiency (syndromeofinappropriatesecretionofantidiuretiehormone, SLADH) means the body antidiuretic hormone (ADH) secretion, or abnormal increase in the role of extraordinary activity, leading to water retention, and increased urinary sodium row of dilution, and other Hyponatremia syndrome. (A) heterologous secretion of ADH following lesions in real terms in the cell can be secreted proteins and their delivery ADH - Neurohypophysis-I: 1. Oat cell carcinoma of the lung cancer, pancreatic cancer, lymph sarcoma, Hodgkin's disease, mesh cell sarcoma, breast cancer, duodenal cancer, bladder cancer, prostate cancer. 2. Lung infection pneumonia, tuberculosis, pulmonary abscess, pulmonary aspergillosis. (B) of the drug or the disease led to the release of ADH too much 1. Central nervous system diseases, brain injury, subdural hematoma formation, subarachnoid hemorrhage, cerebral thrombosis, brain abscess, shrink the brain, the brain of acute infection, tuberculosis or other meningitis. 2. To promote the release of ADH, or to enhance its role in the drug-C-methyl urea, chlorine-Bedin, tricyclic antidepressants (such as clomipramine-), general anesthetics, and drugs such as barbiturates can stimulate the release of ADH, C-methyl urea can increase the activity of ADH. Thiazide diuretics because of their schedule and caused sodium diuresis decline in GFR, and at the same time trigger secretion of ADH, far tubule reabsorption of water, free water clearance rate decreased. Such as anti-cancer drug vincristine, cyclophosphamide may also stimulate the release of ADH. (C) other left atrial pressure dropped capacities to stimulate the receptors, so that the reflex to increase secretion of ADH, found in the mitral stenosis after separation, SLADH can also be found in the adrenal dysfunction, edema, and mucus anterior pituitary dysfunction Endocrine diseases, such as (due to low blood volume or free water damage to the kidneys row); a small number of patients and their SLADH not cause the above link may be of tubular ADH sensitivity to change. ADH secretion and the scope of diseases, a group of lung cancer statistics show that beyond the chest and a half, 85% of the water stress test abnormalities, and chest disease limited to a half of water only 36% of the abnormal stress test. ADH activity so that the increase in the distal convoluted tubule and collecting duct epithelial cells to increase the water permeability, and thus the reabsorption of water, reduce the volume; at the same time as a result of increased blood volume caused by dilution of hyponatremia, inhibited secretion of aldosterone, the third factor Released so that the tubular sodium and uric acid increase in emissions.