Excessive secretion of antidiuretic hormone syndrome

Antidiuretic hormone (Antidiuretic Hormone, ADH) syndrome is the excessive secretion of a variety of reasons caused by endogenous antidiuretic hormone ADH or similar substances secreted continued to make water discharge took place obstacles in order to cause hyponatremia, water retention and Clinical performance. Antidiuretic hormone (Antidiuretic Hormone, ADH) syndrome is the excessive secretion of a variety of reasons caused by endogenous antidiuretic hormone ADH or similar substances secreted continued to make water discharge took place obstacles in order to cause hyponatremia, water retention and Clinical performance. 】 【Diagnosis 1. Hyponatremia, low 130mmol / L, but increased urinary sodium, often more than 20mmol / L. 2. Urine osmotic pressure than plasma. 3. No low-volume performance. 4. Stringent water restrictions correct hyponatremia, a low osmotic pressure in plasma and high urine sodium. 5. Incidence can be found in the original. 【Treatment】 Treatment, the only light restrictions on water every day photo <100ml, symptoms can be improved, weight loss, serum sodium and increased osmotic pressure and urinary sodium excretion to reduce. Weight should slow intravenous infusion of 5% sodium chloride solution 200 ~ 300ml, a few hours in the progressive upgrading of sodium can increase water use furosemide. ADH anti-drug applications, such as norepinephrine may gold-ADH obstruction of the renal tubular reabsorption of water. Lithium has a similar, but more toxic. This disease for the treatment of the most fundamental cause of treatment, need surgery to remove the malignant tumor, chemotherapy with radiation therapy. 【Etiology】 The most common reason is that the tumor tissue and synthesis of autonomy due to the release of ADH, accounting for about 80% of the levy, mainly oat cell lung cancer, pancreatic cancer, duodenal cancer and lymphoma, and so on. Others, such as pneumonia, tuberculosis and under the influence of the hypothalamus - pituitary function of the nerve injury, inflammation, such as tumor neuropathy can also be caused by excessive secretion of ADH. 【Clinical】 In addition to the performance of the disease, intrinsic mainly water retention and hyponatremia. General serum sodium less than 130mmol / L, when sodium <120mmol / L when unable to, loss of appetite, nausea and vomiting, lethargy, irritability and even psychiatric disorders. When sodium <110mmol / L when convulsions, coma or even death. As a result of water retention in general no more than 3 to 4 liters of water and transferred to the parts of cells, it is generally no edema. 】 【Complications Intrinsic to be with renal disease, adrenal insufficiency, chronic heart failure and ascites due to cirrhosis, hypertonic diuretics, as well as the application of hypothyroidism, such as caused by retention of water and / or identification with hyponatremia.