That people want to see HIV vaccine, when available?

The use of vaccines to deal with humanity's many powerful enemies, smallpox, polio, tuberculosis, which fears that people are talking about the disease today has been largely unable to humanity as a whole to bring great harm. However, the number of AIDS invasion, the social consequences of severe, more importantly, not from a pathogenic micro-organisms such as the AIDS virus so that scientists find it difficult to deal with. In 1983 scientists identified HIV, people thought that the emergence of AIDS vaccines is only a short period of time will be able to solve the problem. But more than 20 years have passed, in order to promote education and behavioral intervention such as drug prevention and treatment has achieved considerable success, the AIDS vaccine research has been Shayuergui. To 2003, the world's largest AIDS vaccine clinical research ⅲ period in North America and Thailand failed to develop such a protein subunit vaccine the United States Wake Si Kan (vaxgen) biotechnology company acknowledged that test results showed that the vaccine can not be effective To prevent human infection of HIV. The clinical study started in 1998, Wake Si Kan in Bangkok, Thailand, North America and were not infected with the recruitment of 5009 men and 2545 homosexual volunteers not infected with the virus, drug addicts and AIDS vaccine clinical research ⅲ period, which is So far the largest AIDS vaccine clinical research. However, the end of the study, in addition to the individual small sample size (such as black Africans), there are certain differences in the crowd, the vaccine group and the new infection rate in the placebo group (that is, in the control group) of the new infection rate there is no significant difference -- - Gay male volunteers in the study showed that vaccinated volunteers infected with the AIDS virus to reduce the chance of only 3.8 percent - which means that the vaccine is not to bring effective protection of the human body. In fact, since 1988 the world's first AIDS vaccine candidates entered clinical trials, there have been hundreds of AIDS vaccines into pre-clinical and clinical trials, but so far there is no vaccine has been proven to be effective. Moving target 20 years of research history, virologist and immunologist who had to admit that AIDS vaccine overseas Chinese fertilizer dead whispering sound Miao Guo Fei Xian eight core thirst  milk rice dumplings wrapped in leaves from the armed Kin h   Beach ∫ ti Lan Guo Xuan Miao core harsh education Canadian broom? Researchers million, compared with the AIDS virus 9700 base pairs, the base pairs on almost every individual in the study had 3. Even so, AIDS vaccine is still no major breakthrough, because HIV is an unprecedented, "cunning" virus. People at this stage in vaccine research in the field of accumulated knowledge and experience from a number of major acute infectious diseases, such pathogenic bacteria or viruses are self-limited (rare variation), or researchers can induce the body have a very Strong protective antibodies to remove pathogens. However, human beings had achieved against the experience of other viruses in AIDS vaccine research is difficult to test their abilities significantly. HIV immunologist been likened to the "moving target" because HIV is a retrovirus, the genetic material is rna. rna in the process of reverse transcription-dna to copy the wrong easily occur, and to promote this process occurred in reverse transcriptase and the lack of correction, the virus was able to keep genetic diversity, a lot of strain mutation. In the genetic sequence of the virus constantly changes, their function is extremely conservative, each of the mutated strain is still able to infect human cells. In addition to the "dynamic" and HIV was also "good at hide-and-seek," the virus before it can be integrated into the host chromosome, in order to escape the body's immune system to be cleared. Invasive virus in human cells, the virus would be to cover the surface of sugar-coated, lower-infected cells to express the antigen, and other means to evade the immune system attack. More cunning, the AIDS virus directly attacks the vaccine which is to play a role in the immune system, making the vaccine to increase immunity to become Wuyong Gong. Has been developed human vaccines are the most suitable animal model, experimental use of these animals, researchers can attack the immune protection and drug tests to evaluate the vaccine's efficacy and safety. AIDS vaccine in humans only very close to the infected monkeys carried out using animal models to analyze the body may have the effect of, and the final evaluation can only rely on clinical trials to scrap  CALCINED spinulosa t  founded interpretation? 0 years U.S. National Institutes of Health (nih) in support of the 300-monkey vaccine experiments, each experiment used an average of only 3.7 monkeys far less than sure that the results statistically significant sample, which greatly extended the evaluation of the vaccine Research period of time. [FS: PAGE] At least between gains and losses, are still in a proper way, even though they do not have any AIDS vaccine research, but in the face of this "strong" adversary, immunology and vaccinology has been tremendous. AIDS vaccine research in 20 years, the human immune system for self-awareness and its related fields in the development of more than in the past 200 years combined. Experts say there are immune because of AIDS vaccine research, in the past in order to bacteriologist-based virologist and vaccine research, and finally to make way for the immunologist.